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Mary O. Gray, MD is an assistant professor of medicine in residence in University of California San Francisco, UCSF. Mary Gray received a B.A.S., Biology and English, from Stanford University in 1983 and an M.D. from UC San Diego in 1987. She trained in internal medicine at UC San Diego and in cardiovascular medicine at UC San Francisco. She has been on the faculty in the department of medicine at San Francisco general hospital since 2001 and was appointed director of cardiology and anticoagulation clinics in 2002. She joined the lung biology research center as a principal investigator in April 2004.
Mary O. Gray, MD has research interest in novel strategies, which are needed to protect against cardiac ischemia reperfusion injury.Coronary heart disease is a leading cause of death worldwide. Existing therapies improve prognosis associated with acute coronary syndromes including unstable angina.
However, patients with these disorders remain at high risk of myocardial infarction, heart failure, and death. Mechanisms of ischemia reperfusion injury and strategies to reduce heart, brain, and renal damage should be further explored. They have begun investigation of how other signaling pathways modulate beneficial effects of preconditioning. Protein kinase C, PKC precipitates mitochondrial dysfunction and tissue necrosis by enhancing formation of toxic reactive oxygen species ROS. Similarly, poly ADP ribose polymerase 1 can promote contractile dysfunction and infarction by depleting cardiac NAD plus and ATP stores. Complementary approaches using in vitro, ex vivo, and in vivo models may lead to new strategies for prevention of ischemic heart disease.

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